Suppression of renal sympathetic activity with potassium supplement in DOCA-salt rats.

摘要: We studied the involvement of renal sympathetic nervous system activity in antihypertensive and natriuretic effects potassium supplement DOCA-salt treated rats. Systolic blood pressure rats rose substantially, reaching 181±3mmHg after 4 weeks administration. In contrast, 1% KCl solution attenuated development hypertension until fourth week (120±1mmHg). After 4-week treatments, norepinephrine turnover rate was calculated from decline specific injection dl-3H-norepinephrine. It markedly accelerated as compared to control significantly restored normal increased Taken together, evidence presented suggests that normalization tone may be involved hypertensive