Alcohol ingestion decreases both diurnal and nocturnal secretion of leptin in healthy individuals.

摘要: OBJECTIVE Neuropeptide Y (NPY) stimulates appetite and increases food intake. Leptin inhibits NPY. It is not known whether alcohol influences any of these factors, but it has been suggested that in man. The primary objective this investigation was to determine ingestion ethanol leptin secretion normal subjects. SUBJECTS AND DESIGN Fourteen healthy, non-obese subjects both sexes (7 F/7 M) were included. They divided into two groups (I II; 8/6). All investigated on occasions. On one occasion ingested, the other drinking water given. experiments took place random order, week apart. In group I (A = alcohol; B = water) performed during day. II carried out night (C = alcohol; D = water). Each alcoholic drink contained 0·45 g ethanol/kg. drinks given at 08.00, 09.30 11.00 hours A B, 18.00, 20.00 22.00 hours C D. Venous blood samples collected before, after over periods 6 h 14 h II. MEASUREMENTS Serum concentrations leptin, insulin-like growth factor 1 (IGF-1), IGF binding protein (IGFBP-1), insulin, cortisol, testosterone, plasma glucose determined. RESULTS Group I serum levels declined day men women regardless or had administered morning. Since general markedly higher than men, all changes water/alcohol transformed percentage make them comparable between sexes. When decline a 6-h period (08.00–24.00 hours) expressed by decremental area under curve (AUC08−14), became evident inhibited secretion, inasmuch as area, obtained alcohol, significantly larger (124 ± 17 vs. 57 ± 8; P < 0·01). Similar insulin water. Group II increased initial part (18.00–20.00 hours). shown incremental (AUC18−24) which 53 ± 18 113 ± 15 (P < 0·01). As concentration began fall, its inhibitory effect gradually disappeared, when AUCs representing entire determined water, they different. glucose, IGF-1 cortisol found IGFBP-1 level increased, so until commencing ingestion. CONCLUSION Ingestion moderate amounts an subjects. may be direct rather indirect, since several factors affect are influenced alcohol. tempting speculate might serve appetizer decreasing additional studies necessary prove hypothesis previous have long-term acute hunger.