Perinatal SSRI exposure affects brain functional activity associated with whisker stimulation in adolescent and adult rats

摘要: Selective serotonin reuptake inhibitors (SSRI), such as fluoxetine, are used first-line antidepressant medication during pregnancy. Since SSRIs cross the placenta unborn child is exposed to maternal SSRI medication, resulting in, amongst others, increased risk for autism in offspring. This likely results from developmental changes brain function. Studies employing rats lacking transporter have shown that elevations levels particularly affect development of whisker related part primary somatosensory (barrel) cortex. Therefore, we hypothesized level disturbances alter activity stimulation. We treated female dams with fluoxetine or vehicle gestational day 11 onwards 21 days. investigated offspring’s stimulation using functional magnetic resonance imaging (fMRI) at adolescence and adulthood. Our indicate adolescent offspring displayed hippocampal subareas mammillary body thalamus. Adult exhibited activation areas associated (higher) sensory processing memory hippocampus, perirhinal entorhinal cortex, retrospinal granular piriform cortex secondary visual data imply perinatal exposure leads complex alterations networks involved perception processing.