Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease

摘要: Retinoic acid (RA) plays an important role in the commitment, maturation and survival of neural cells. Recently, RA was pointed as a therapeutic option for some neurodegenerative diseases, including Parkinson's disease (PD). The administration has been defying, this sense we have previously developed novel RA-loaded polymeric nanoparticles (RA-NPs) that ensure efficient intracellular transport controlled release RA. Herein, show nanoformulation neuroprotective effect on dopaminergic (DA) neurons 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mouse model PD. results showed RA-NPs significant reduction DA neuron loss substantia nigra (SN) well their neuronal fiber/axonal innervations striatum. Furthermore, observed increase expression levels transcription factors Pitx3 Nurr1 by RA-NPs, showing its supportive development functional maintenance This is first study can be innovative strategy to halt progression PD pathogenesis, suggesting could particular interest new approaches therapeutics.