Genetic variation in the interleukin-28B gene is not associated with fibrosis progression in patients with chronic hepatitis C and known date of infection.

摘要: Polymorphisms in the interleukin-28B (IL28B) region are associated with spontaneous and treatment-induced viral clearance hepatitis C virus (HCV) infection. Nevertheless, it is unknown whether genetic variation at IL28B locus influences natural history of chronic HCV Thus, we asked an association between polymorphisms liver fibrosis progression existed. We studied 247 consecutive patients HCV, accurate estimate date infection, a biopsy performed before any treatment. No patient had alcohol abuse or coinfection other viruses. assessed role rs8099917 rs12979860 effect host environmental factors on progression. Blood transfusion (75%) was main modality Median age infection 21 years, median interval 25 years. One hundred twenty-nine (52%) were infected by HCV-1, 74 (30%) HCV-2, 34 (14%) HCV-3, 10 (4%) HCV-4. Bridging fibrosis/cirrhosis (Ishak ≥4) detected 24% patients. Age marked both linear model Cox proportional-hazard regression (P < 2E-16). A 12.1% increase hazard advanced estimated for each additional year suggesting that this major explanatory variable cohort. Male gender 0.05), genotype 3 0.001) steatosis 0.05) also faster Conversely, two no impact Conclusion: In known not rate risk developing fibrosis. (HEPATOLOGY 2011;)