Long-term treatment of spasticity with botulinum toxin type A: an analysis of 1221 treatments in 137 patients

作者: B. Mohammadi , S. Abdoulrahmani Balouch , R. Dengler , K. Kollewe

DOI: 10.1179/016164109X12478302362734

关键词:

摘要: Abstract Objectives: Spasticity is a complex disorder that causes significant disability in affected patients. We here present long-term results of botulinum toxin type A (BoNT-A) treatment spasticity various etiologies the upper and lower limbs. Patients methods: evaluated BoNT-A with Dysport Botox for up to 12 years 137 patients etiologies. The focus was laid on efficacy, dosage, safety side effects over time retrospective analysis database our movement clinic. Results: mean clinical benefit, latency duration response were comparable both products. Side generally mild two found negative correlation between from onset start degree improvement after treatment. Conclusion: Our data confirm efficacy different over...

参考文章(42)
U. Bettig, K. Wohlfarth, R. Dengler, U. Neyer, H. H. Janzik, Local botulinum toxin in the treatment of spastic drop foot. Journal of Neurology. ,vol. 239, pp. 375- 378 ,(1992) , 10.1007/BF00812153
Lincoln N, Leadbitter D, ASSESSMENT OF MOTOR FUNCTION IN STROKE PATIENTS Physiotherapy. ,vol. 65, pp. 48- 51 ,(1979)
R R Young, Spasticity: a review. Neurology. ,vol. 44, ,(1994)
Gary E. Borodic, Robert Ferrante, L. Bruce Pearce, Karen Smith, Histologic assessment of dose‐related diffusion and muscle fiber response after therapeutic botulinum a toxin injections Movement Disorders. ,vol. 9, pp. 31- 39 ,(1994) , 10.1002/MDS.870090106
B. Mohammadi, N. Buhr, H. Bigalke, K. Krampfl, R. Dengler, K. Kollewe, A long-term follow-up of botulinum toxin A in cervical dystonia. Neurological Research. ,vol. 31, pp. 463- 466 ,(2009) , 10.1179/174313209X405137
Hilke Göschel, Kai Wohlfarth, Jürgen Frevert, Reinhard Dengler, Hans Bigalke, Botulinum A Toxin Therapy: Neutralizing and Nonneutralizing Antibodies—Therapeutic Consequences Experimental Neurology. ,vol. 147, pp. 96- 102 ,(1997) , 10.1006/EXNR.1997.6580
Jens D. Rollnik, Mike Matzke, Kai Wohlfarth, Reinhard Dengler, Hans Bigalke, Low-Dose Treatment of Cervical Dystonia, Blepharospasm and Facial Hemispasm with Albumin-Diluted Botulinum Toxin Type A under EMG Guidance European Neurology. ,vol. 43, pp. 9- 12 ,(2000) , 10.1159/000008121
Frank Reiter, Maura Danni, Giovanni Lagalla, Gabriella Ceravolo, Leandro Provinciali, Low-dose Botulinum Toxin With Ankle Taping for the Treatment of Spastic Equinovarus Foot After Stroke Archives of Physical Medicine and Rehabilitation. ,vol. 79, pp. 532- 535 ,(1998) , 10.1016/S0003-9993(98)90068-5