The Effect of Neural Lesion Type on Botulinum Toxin Dosage: A Retrospective Chart Review

摘要: Background It is difficult to compare the dosage of botulinum toxin between different neurologic conditions because methods reported dosages. Botulinum used manage spasticity in variety conditions, and it important for clinicians know whether there are differences injected on basis etiology spasticity. Objective To determine type neural lesion influences required Design Retrospective chart review. Setting Review patients who visited an outpatient clinic. Participants We assessed medical charts from 99 with stroke, multiple sclerosis (MS), cerebral palsy (CP) (n = 33 each etiology). collected information such as age, gender, weight, time lesion, total (per person, per limb, muscle), injection location, injections cycles. Interventions None. Main Outcome Measurements OnabotulinumtoxinA dose – one leg was calculated a sum units all muscles. Results Total 161 ± 19 (mean standard error mean) 175 13 CP, 225 18 MS. The legs (normalized body weight; units/kg) significantly 3 groups (stroke, MS; P  = .001). Subsequent post-hoc tests revealed that MS greater (88%) than stroke ( Hip adductors hamstrings were most commonly but toe muscles whereas plantar flexors evenly patient groups. Conclusion In our practice, we found treating people greatest toxin, followed by CP then stroke.