Structure and function of medial temporal and posteromedial cortices in early Alzheimer's disease.

摘要: Medial temporal lobe (MTL) atrophy and posteromedial cortical hypometabolism are consistent imaging findings in Alzheimer's disease (AD). As the MTL memory structures affected early course of AD by neurofibrillary tangle pathology, metabolic abnormalities have been postulated to represent remote effects alterations. In this study, we investigated with functional MRI (fMRI) structure-function relationship between regions, including retrosplenial, posterior cingulate precuneal cortices, 21 older controls (OCs), 18 subjects amnestic mild cognitive impairment (MCI) 16 patients during a word list learning task. voxel-based morphometric volumetric analyses, MCI showed smaller entorhinal volume than OCs (P = 0.0001), whereas there was no difference hippocampal or volume. patients, as compared pronounced loss 0.01) 0.001) regions. The normal pattern fMRI task-induced deactivation active encoding words observed bilaterally OCs, but only restricted unilateral left areas patients. Across all subjects, more extensive retrosplenial function significantly related 0.0002) These demonstrate that dysfunction characteristics prodromal AD, precede and/or overwhelm hippocampus cortices. Disturbances associated morphological changes across continuum from aging clinical AD.