MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment

摘要: Objective: To compare the patterns of gray matter loss in subjects with amnestic mild cognitive impairment (aMCI) who progress to Alzheimer disease (AD) within a fixed clinical follow-up time vs those remain stable. Methods: Twenty-one aMCI were identified from Mayo Clinic Alzheimer9s research program remained clinically stable for their entire observed course (aMCI-S), where minimum required MRI last assessment was 3 years. These age- and gender-matched 42 progressed AD 18 months (aMCI-P). Each subject then control subject. Voxel-based morphometry (VBM) used assess atrophy aMCI-P aMCI-S groups compared group, each other. Results: The group showed bilateral affecting medial inferior temporal lobe, temporoparietal association neocortex, frontal lobes, controls. no regions when When directly, greater posterior cingulate, precuneus, anterior lobes than group. Conclusions: are typical AD. lack is consistent notion that on at baseline map well onto subsequent course. GLOSSARY: = disease; ADNI Disease Neuroimaging Initiative; ADPR Patient Registry; ADRC Research Center; impairment; APOE e4 apolipoprotein epsilon 4; AVLT Auditory Verbal Learning Test; CDR-SB CDR sum boxes; DCT discrete cosine transformation; FDR false discovery rate; FWHM full-width half-maximum; GM matter; MMSE Mini-Mental State Examination; MNI Montreal Neurological Institute; NIA National Institute Aging; TIV total intracranial volume; VBM voxel-based morphometry; WM white WMH hyperintensity.