The Role of Hypertensive Vascular Disease in Brain Aging and Neurodegeneration

摘要: Brain aging, the phenomenon by which passage of chronological time is associated with reduced brain volume, important because it regarded as a key component increased dementia risk. The main purpose this thesis to present model and supporting data that enhances knowledge underlying processes drive aging This has been done using structural functional MRI scans from Cardiovascular Health Study-Cognition Study (CHS-CS), longitudinal community cohort study elderly individuals possesses extensive clinical neuropsychological data. defended in dissertation states relationship between older age lower gray matter volume not strictly function time. Rather, correlated vascular diseases themselves are driving force behind aging. Most importantly, three entities disease, neurodegeneration overlap strategic areas brain. Thus, large factor risk there common serve sites synergy age, can summate thus amplify for cognitive impairment dementia. Using whole method analyzing scans, we have found reflected white hyperintense lesions (WMHL) jointly affect known be targeted they interact these regions. Finally, results perfusion imaging will reported showing hypertension predictor regional cerebral blood flow. Taken together, interpreted support following model: changes an modulated hypertensive disease. Additionally, damage exerted neurodegenerative on also modified anatomical occurs include functions such hippocampus, cingulate gyrus, precuneus. several broad implications. First, suggests related atrophy perhaps even itself magnitude if either prevented or better managed. Second, reduction may providing additional reserve. Third, regions provide basis further therapeutic targets.