Brain white matter hyperintensities: relative importance of vascular risk factors in nondemented elderly people.
作者： Alison D. Murray , Roger T. Staff , Susan D. Shenkin , Ian J. Deary , John M. Starr
DOI: 10.1148/RADIOL.2371041496
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摘要: PURPOSE: To prospectively determine whether there is an association between brain white matter signal hyperintensities on magnetic resonance (MR) images and potential risk factors for cerebral ischemia in a well-characterized narrow age cohort of nondemented community-dwelling elderly people. MATERIALS AND METHODS: The study population consisted surviving members the Aberdeen 1921 Birth Cohort, subsample participants 1932 Scottish Mental Survey who were born 1921. With permission local ethics committee with informed written consent, 106 subjects (62 men, 44 women) aged 78–79 years underwent T2-weighted MR imaging. Brain scored semiquantitatively deep periventricular hyperintensities. Vascular clinical measures potentially associated included hypertension, diabetes, cerebrovascular disease, smoking, body mass index grade, respiratory function levels (forced expi...
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