作者: Uwe Wollina , Georgi Tchernev
DOI: 10.1007/S10354-013-0193-5
关键词:
摘要: Basal cell carcinoma (BCC) is the most common skin malignancy worldwide. Ultraviolet light exposure best known exogenous factor in BCC development. This also target for primary prevention. Advanced include locally advanced tumors and metastatic tumors. Prognosis worse compared to stage I II BCCs. Mohs or micrographically controlled surgery gold standard of treatment. In patients with that cannot be completely removed radiotherapy was only alternative past. More recently new drugs targeted therapy signaling pathways like sonic hedgehog epidermal growth receptor became available. small molecules are under investigation. Since complete response rates limited, future research has evaluate their combination surgery.