Electrochemotherapy for the treatment of recurrent head and neck cancers: preliminary results

摘要: Aims and background Electrochemotherapy is a tumor ablation modality providing delivery into the cell interior of impermeant or poorly permeant chemotherapeutic drugs such as cisplatin bleomycin. A locally applied electrical field enhances membrane permeability allowing intracellular accumulation agent. The aim study was to evaluate effectiveness ECT for treatment group patients affected by recurrent extended primary head neck cancer not suitable standard therapeutic options. Methods design From April 2009 January 2011, we treated with electrochemotherapy total 15 cancers, 13 squamous carcinoma, 1 basaloid carcinoma Merkel carcinoma. Electrical pulses were delivered 33 lesions (3 primaries, 30 recurrences) after an intravenous bolus injection dose 15,000 IU/m2 In 3 cases, lesion pathologic lymph node. Results Of 31 assessable study, 19 (61.5%) showed complete response, 10 (32.5%) partial (3%) stable disease progression disease. objective response 2 months procedure 94%. All that underwent regression less than cm in their maximum diameter. cases nodes no response. After follow-up 20 months, 29% alive free disease, 50% 14% died 7% other causes. Conclusions Our confirms local control