Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients.
作者： Yanqiu Wang , Zhengzeng Jiang , Chen Xu , Hao Wang , Lijie Tan
DOI: 10.1186/S12885-019-5450-6
关键词:
摘要: Since Mesenchymal epithelial transition (MET) amplification has been regarded as a potential treatment target, the knowledge of its prevalence and prognostic importance is crucial. However, clinical pathologic characteristics are not well known in esophageal squamous cell carcinoma (ESCC). We investigated MET gene status with fluorescence situ hybridization (FISH) assay 495 ESCC cases using tissue microarrays. Prognostic significance correlations various clinicopathological parameters was evaluated. Among patients, 28 (5.7%) were FISH positive, including 5 (1%) true amplification. There no statistically significant associations between FISH-positivity clinicopathologic characteristics. A significantly poorer prognosis observed patients (disease free survival/DFS, P < 0.001 overall survival/OS, P = 0.001). Multivariate analysis revealed an independent factor for DFS (hazard ratio/HR, 1.953; 95% confidence interval/CI, 1.271–2.999; P = 0.002) OS (HR, 1.926; CI, 1.243–2.983; P = 0.003). associated (P = 0.022 0.020) (P = 0.046 0.024) both stage I-II III-IVa ESCC. No statistical (DFS, P = 0.492 OS, P = 0.344) detected FISH-negativity. Increased copy number ESCC, might have potentially up-staged by increased number. The results indicate that very promising parameter, therapy follow-up plans.
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