MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
作者： J. A. Engelman , K. Zejnullahu , T. Mitsudomi , Y. Song , C. Hyland
关键词:
摘要: The epidermal growth factor receptor (EGFR) kinase inhibitors gefitinib and erlotinib are effective treatments for lung cancers with EGFR activating mutations, but these tumors invariably develop drug resistance. Here, we describe a gefitinib-sensitive cancer cell line that developed resistance to as result of focal amplification the MET proto-oncogene. inhibition signaling in cells restored their sensitivity gefitinib. was detected 4 18 (22%) specimens had or erlotinib. We find causes by driving ERBB3 (HER3)–dependent activation PI3K, pathway thought be specific EGFR/ERBB family receptors. Thus, propose may promote other ERBB-driven well.
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