Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis

摘要: THE proteins Gab1 and the related DOS (for 'daughter of seven-less') each bind to substrates tyrosine kinases like Grb2 or Corkscrew, act in signalling pathways downstream kinase receptors1–3. Here we show that interacts directly with c-met-encoded receptor but not a number other from different subfamilies. A newly identified proline-rich domain is responsible for binding this protein tyrosine-phosphorylated bidentate docking site4,5 c-Met. Expression epithelial cells sufficient induce c-Met-specific activities6–9, including branching morphogenesis. Thus have discovered new phosphotyrosine interaction shown substrate c-Met mediates