Synergistic actions of platelet-derived growth factor and the insulin-like growth factors in vivo.

摘要: Topical application of growth factors has been shown to benefit both normal and impaired wound healing. In tissue repair, resident cells produce a "cocktail" various types that overlap in function. vitro studies have proved factor combinations can act synergistically enhance cellular function beyond achieved with individual factors. To determine whether similar synergistic effect vivo, we applied topically full-thickness skin wounds created genetically diabetic mice. The C57BL/KsJ-db/db mouse is obese insulin-resistant diabetes, it this markedly platelet-derived factor, insulin-like factor-I, or factor-II enhances healing model. Marked synergism was found when were combined augmentation closure by the allowed for improved repair at doses ineffective individually. addition factor-I insulin produced no significant synergism. Because multiple are released during process, not surprising their combination further Growth should become an important armamentarium treatment chronic, nonhealing wounds.