YAC-1 MHC class I variants reveal an association between decreased NK sensitivity and increased H-2 expression after interferon treatment or in vivo passage.

摘要: Two H-2 negative variants of the YAC-1 lymphoma were selected by mutagenization and sequential in vitro selections compared with wild-type cells for changes NK sensitivity expression after interferon treatment or vivo passage. The low expressor had similar sensitivity. However, IFN-beta recombinant IFN-gamma pretreatments increased protected them from lysis, whereas variants, which remained negative, not often more sensitive to lysis. similarly susceptible as three other cellular effects interferon: protection virus infection, modulation Con A capping, inhibition cell proliferation. Thus, only interferon-mediated effect that distinguished was inability former increase their decrease line showed decreased In contrast, passaged no reexpression H-2, sensitive. altered responses passage specific loss down-regulation because Thy-1 (H-2 positive) behaved all respects. This study supports hypothesis may function eliminate host fail express stimulation during an immune response; such are a potential threat they escape recognition T lymphocytes despite viral tumor-associated antigens.