Functional Domains of Adenovirus E1A Oncogenes Which Control Interactions with Effectors of Cellular Immunity

摘要: Group A adenoviruses, such as adenovirus type 12 (Ad12), are oncogenic in newborn rodents, inducing tumors the majority of animals within 4 months (Trentin et al. 1962). The group C 2 (Ad2) or 5 (Ad5), on other hand, nononcogenic (Huebner 1967). Both groups viruses transform rodent cells vitro (Bernards 1982). transforming ability these two is encoded E1 region. Two viral genes, E1A and E1B, required for transformation cultured cells. gene alone can immortalize primary rat (Houweling 1980). Complete, high-efficiency requires, however, that E1B be coexpressed with (Barker Berk 1987). does not show detectable activity even when its expression controlled by a constitutionally active promoter (van den Elsen 1983). Although genes under normal conditions cooperate to cells, predominates determining phenotype tumorigenic potential transformed (Sawada 1985). Mammary tumorigenesis D Ad9 requires functions E4 region from right end genome (Javier 1991, 1992). solely responsible difference oncogenicity (tumorigenic) Ad26 (non-tumorigenic).