Tumor suppressive functions of ceramide: evidence and mechanisms

摘要: Studies over the past two decades have identified ceramide as a multifunctional central molecule in sphingolipid biosynthetic pathway. Given its diverse tumor suppressive activities, molecular understanding of action will produce fundamental insights into processes that limit tumorigenesis and may identify key targets for therapeutic intervention. Ceramide can be activated by array stresses such heat shock, genotoxic damage, oxidative stress anticancer drugs. triggers variety anti-proliferative cellular programs apoptosis, autophagy, senescence, necroptosis activating or repressing effector molecules. Defects generation metabolism cancer contribute to cell survival resistance chemotherapy. The potent versatile activity profile has motivated drug development efforts (re-)activate established tumors. This review focuses on our current functions highlights potential downstream which are involved action.