Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions.

摘要: Both cholecystokinin (CCK) antagonists and N-methyl-D-aspartate (NMDA) block or reduce the development of morphine tolerance in several analgesic assays. The present experiments were performed to assess ability CCK antagonist proglumide NMDA MK-801 affect aversive properties as indexed by conditioned taste aversion (CTA) learning. Specifically, male Sprague-Dawley rats exposed either vehicle (5 mg/kg) combination with mg/kg; Experiment 1), (0.1 2) naloxone (1, 3.2 3). Saccharin was then presented followed an injection (10 mg/kg). Animals preexposed acquired attenuated morphine-induced saccharin. While neither nor had effect on this attenuation, blocked effects preexposure, suggesting that may be involved (or their modulation drug exposure). That attenuating preexposure a CTA can suggests weakening chronic use prevented, have implications for overall acceptability.