Nutraceutical strategies for ameliorating the toxic effects of alcohol.

摘要: Abstract Rodent studies reveal that oxidative stress, much of it generated via induction/activation NADPH oxidase, is a key mediator number the pathogenic effects chronic ethanol overconsumption. The highly reactive metabolite acetaldehyde driver this and doubtless works in other ways to promote alcohol-induced pathology. Effective antioxidant measure may therefore be useful for mitigating adverse health consequences alcohol consumption; spirulina have particular utility regard, as its chief phycochemical phycocyanobilin has recently been shown function an inhibitor certain oxidase complexes, mimicking physiological role chemical relatives biliverdin/bilirubin respect. Moreover, nutraceuticals, including taurine, pantethine, lipoic acid, potential boost activity mitochondrial isoform aldehyde dehydrogenase, ALDH-2, accelerating conversion acetate (which arguably protective effects). Little noticed clinical conducted nearly three decades ago reported pre-ingestion either taurine or pantethine could blunt rise blood following consumption. Other evidence suggests acid within mitochondria maintain dehydrogenase reduced active conformation; impact agent on metabolism however received little no study. Studies evaluating nutracetical strategies prevention hangovers – which likely are mediated by represent quick, low-cost way identify nutraceutical regimens merit further attention their Measures preserve ALDH-2 also important potential, enzyme functions physiologically protect cells from toxic aldehydes oxidant stress.