Willgerodt-Kindler reaction at room temperature: Synthesis of thioamides from aromatic aldehydes and cyclic secondary amines

摘要: Abstract A simple method for the synthesis of thioamide derivatives in DMSO at room temperature and 120 °C has been developed. Total 27 compounds were prepared under both conditions via a one-pot, three component reaction between substituted aromatic aldehydes, elemental sulfur powder, cyclic secondary amines. By optimizing mole ratio powder amines, we have successfully carried out Willgerodt-Kindler aldehydes temperature. At 120 °C, it is catalyst free with lower time whereas temperature, due to additional amine molecule, On gram-scale, attempted good yields.