摘要: Publisher Summary This chapter discusses naturally occurring taxoids. Taxoids are a structurally homogeneous class of compounds that occur in two genera the yew family (Taxus and Austrotaxus). Ancient trees like gingko storehouse biologically active compounds. having tricyclopentadecane ring system or closely related skeleta. Two planar representations taxane use—namely, (1) linear, (2) angular. Taxanes considered most widespread skeletal types In taxanes, site main structural variation terpenoid core is C-4/C-20/C-5 moiety. The tertiary hydroxyl at C-4 generally esterified, but secondary group C-5 primary one C-20 can both free esterified form. Oxo bridges always β, an important observation regard to biogenesis these types. All natural with exception taxagifine its derivatives have double bond C-11/C-12. plays role stabilizing twist-boat conformation cyclooctane moiety taxanes preventing transannular interaction between substituents C-3α C-12α.
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