The Effects of Ejection Fraction on N-Terminal ProBNP and BNP Levels in Patients With Acute CHF: Analysis From the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study
作者： Michelle O'Donoghue , Annabel Chen , Aaron L. Baggish , Saif Anwaruddin , Daniel G. Krauser
DOI: 10.1016/J.CARDFAIL.2005.04.011
关键词:
摘要: Abstract Background Limited data exist regarding the impact of left ventricular ejection fraction (LVEF) on N-terminal pro-brain natriuretic peptide (NT-proBNP) and B-type (BNP) levels in patients with acute congestive heart failure (CHF). Methods Results LVEF were analyzed for 153 subjects CHF. ≥50% was defined as non-systolic CHF (NS-CHF); >50% systolic (S-CHF). 76 (49.7%) had NS-CHF. Median NT-proBNP BNP significantly higher among S-CHF (6196 pg/mL, 592pg/mL, respectively) compared those NS-CHF (2849 259 respectively). With optimal cut-points, a false-negative rate 7% observed both assays S-CHF. Among NS-CHF, (20%) than did (9%; P Conclusion Levels are lower NS-CHF; however, contrast to NT-proBNP, may be falsely negative up 20% does not correlate symptom severity appears superior evaluation suspected preserved LVEF.
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