CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection.
作者： E Legac , B Autran , H Merle-Beral , C Katlama , P Debre
DOI: 10.1182/BLOOD.V79.7.1746.1746
关键词:
摘要: CD7 and CD57 are two cell surface molecules related to the differentiation or functional stages of CD4+ T cells. The CD4+CD7- cells represent a minor subset in normal individuals considered contain counterpart Sezary cells; CD4+CD57+ peripheral blood lymphocytes (PBL) detectable long- term renal allograft recipients. We compared expression these markers on lymphoid organs from human immunodeficiency virus (HIV)-infected patients. Our results indicate that PBL do not express were poorly responsive anti-CD3 monoclonal antibody (MoAb), activation being restored by addition anti-CD28 MoAb. This is increased during HIV infection, its progressive expansion mirrors both absolute relative decrease lack correlated with acquisition because CD4+CD7-CD57+ major component HIV-infected suggest presence lymphocytes, which behave as previously defined helper subsets, may participate immune dysfunction observed infection.
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bloodjournal.org参考文章(29)
V Daniel, G Opelz, K Schimpf, Lymphocyte autoantibodies and alloantibodies in HIV-positive haemophilia patients. Clinical and Experimental Immunology. ,vol. 75, pp. 178- 183 ,(1989)
Kimitaka Sagawa, Shizuo Hagiwara, Kaori Yasuda, Mitchel Mitsuo Yokoyama, Expression Profiles of T Cell Associated Antigens on Adult T Cell Leukemia Cells: Results of a Workshop Study Springer, New York, NY. pp. 361- 369 ,(1986) , 10.1007/978-1-4613-8587-5_29
Charles M Balch, T. Abo, A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). Journal of Immunology. ,vol. 127, pp. 1024- 1029 ,(1981)
L. Koulova, Soo Young Yang, B. Dupont, Identification of the anti-CD3-unresponsive subpopulation of CD4+, CD45RA+ peripheral T lymphocytes. Journal of Immunology. ,vol. 145, pp. 2035- 2043 ,(1990)
T A Springer, M W Makgoba, D Stephany, S O Sharrow, S Shaw, M E Sanders, H A Young, Human memory T lymphocytes express increased levels of three cell adhesion molecules (LFA-3, CD2, and LFA-1) and three other molecules (UCHL1, CDw29, and Pgp-1) and have enhanced IFN-gamma production. Journal of Immunology. ,vol. 140, pp. 1401- 1407 ,(1988)
F Baujean, A Senik, E Leroy, J P Vernant, Z Mishal, M Divine, C F Calvo, J P Farcet, M H Ben Aribia, M F Gourdin, Persistence of T8+/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogeneic bone marrow transplantation. Journal of Immunology. ,vol. 137, pp. 2180- 2189 ,(1986)
L Moretta, A Velardi, C E Grossi, M C Mingari, Functional analysis of cloned germinal center CD4+ cells with natural killer cell-related features. Divergence from typical T helper cells. Journal of Immunology. ,vol. 137, pp. 2808- 2813 ,(1986)
M López-Botet, M O de Landaźuri, F Sánchez-Madrid, M Rincón, A C Carrera, Triggering of co-mitogenic signals in T cell proliferation by anti-LFA-1 (CD18, CD11a), LFA-3, and CD7 monoclonal antibodies. Journal of Immunology. ,vol. 141, pp. 1919- 1924 ,(1988)
P L Amlot, A Akbar, G Janossy, H P Kocher, B Ryffel, H Gram, M H Schreier, G Heinrich, Characterization of a human T cell-specific chimeric antibody (CD7) with human constant and mouse variable regions. Journal of Immunology. ,vol. 143, pp. 3589- 3597 ,(1989)
L L Lanier, M R Loken, Human lymphocyte subpopulations identified by using three-color immunofluorescence and flow cytometry analysis: correlation of Leu-2, Leu-3, Leu-7, Leu-8, and Leu-11 cell surface antigen expression. Journal of Immunology. ,vol. 132, pp. 151- 156 ,(1984)