CD4+CD7− T Cells: A Separate Subpopulation of Memory T Cells?

作者: Uwe Reinhold , Hinrich Abken

DOI: 10.1023/A:1027318530127

关键词:

摘要: The CD7 molecule is apparently involved in T cell activation but absent a substantial subpopulation of human cells under physiological and certain pathological conditions. majority CD7− expresses TCR α/β CD4+ helper CD45R0+CD45RA− memory phenotype. After birth, percentages absolute numbers circulating increase significantly during aging. A number molecules thought to be organ-specific homing are preferentially expressed within the subset CD4+CD7− cells. Specific absence antigen expression on observed variety pathologic conditions such as cutaneous lymphoma, HIV infection, rheumatoid arthritis, kidney transplantation. Current vitro results suggest that specific downregulation reflects separate stable differentiation state occurring late immune response. Expansion vivo has been found diseases associated with chronically repeated stimulation. potential pathophysiological significance this discussed.

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