Increased expression of a novel early activation surface membrane receptor in cutaneous T cell lymphoma cells.
作者： Maria Nikolova , Abdul Tawab , Anne Marie-Cardine , Martine Bagot , Laurence Boumsell
DOI: 10.1046/J.1523-1747.2001.01305.X
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摘要: Using a newly generated monoclonal antibody we identified the 96 kDa transmembrane receptor SC5 expressed simultaneously on human Sezary cell line and minor T subset in normal individuals. antigen was detected mostly CD45RO+ lymphocytes from both CD4+ CD8+ subsets as well natural killer B lineage cells. surface expression increased very early after polyclonal stimulation of CD3+ cells due to transfer intracellular molecules membrane. Engagement by its inhibited anti-CD3-induced proliferation cytokine secretion peripheral blood clones, whereas did not affect cytotoxic activity CD8+ T clones. Extensive phenotypic analysis revealed that percentage SC5+ circulating syndrome patients significantly comparison with controls (p
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