The “Minimal Essential MHC” Revisited: Both Peptide‐Binding and Cell Surface Expression Level of MHC Molecules are Polymorphisms Selected by Pathogens in Chickens

摘要: Birds, like mammals, have a highly polymorphic MHC that determines strong allograft rejection. However, in contrast to there are number of viral diseases for which resistance and susceptibility determined by particular chicken haplotypes. We found certain common haplotypes express only one class I molecule at high levels. The selection on single gene should be strong, the situation mammals. peptide motifs dominant molecules from they can explain outcome infections with small virus. strongest association is B21 haplotype classical Marek's disease virus, relatively large pathogen any find peptides. In 40 lines, level expression correlates MHC-determined disease, most susceptible B19 highest resistant lowest expression. Thus, cell surface appears polymorphism under infectious pathogens, just peptide-binding specificity. speculate these differences another manifestation simple chickens, human mouse averaged out.