Deliberations and Evaluations of the Approaches, Endpoints and Paradigms for Selenium and Iodine Dietary Recommendations

摘要: Information is presented regarding the approaches that have been used to establish dietary recommendations for selenium and iodine. In case of selenium, activity selenoenzyme glutathione peroxidase has served as a convenient biochemical endpoint forjudging nutritional status. However, there are differences opinion among various nutritionists whether full expression this enzymatic required adequate nutriture, thereby resulting in recommendations. Endpoints assessing overexposure much less satisfactory, but toxicological standards nevertheless established. Thus far, no attempted shift paradigm determining away from prevention deficiency disease chronic degenerative (e.g., cancer). iodine, urinary excretion element most widely Numerous epidemiological surveys conducted determine level iodine consistent with goiter, common deficiency. Because essentially quantitatively excreted urine, determination latter goitrous areas will allow an almost direct estimation those intakes at risk developing disease. Iodine toxicity complicated by fact some persons quite tolerant whereas others highly sensitive it. There relatively complete data sets concerning exposure vs. human health effects both so sounder bases probably exist their than many other trace elements.