Prognostic factors for survival after stereotactic radiosurgery vary with the number of cerebral metastases

作者: Michael L. DiLuna , Joseph T. King , Jonathan P. S. Knisely , Veronica L. Chiang

DOI: 10.1002/CNCR.22367

关键词:

摘要: BACKGROUND. Little is understood about the factors that influence survival in patients who undergo gamma-knife stereotactic radiosurgery (SRS) for brain metastases. METHODS. Demographic, disease, treatment, and data on 334 with intracranial metastases underwent initial SRS from 1998 to 2004 were abstracted treatment records Connecticut Tumor Registry. Multivariate analysis was used identify independently affected survival. RESULTS. The median age of patient population 57.3 years. The number lesions treated a single session 2 (range, 1–36 treated). most common tumor histologies nonsmall cell lung carcinoma (36%), breast cancer (16%), melanoma (16%). Three hundred (90%) had confirmed deaths; after 8.1 months. Survival significantly better 1 3 (median, 8.5 months) compared ≥4 6.3 months; hazard ratio [HR], 0.65; P = .003). In subgroup metastases, systemic control (HR, 0.49; < .001), 0.57; .003), total volume 5 cc .002) associated increased survival, esophageal 2.36; .042) decreased survival. only <45 years 0.39; .006); 2.32; .008) receipt chemotherapy 2.59; .077) Sex, race, location, whole-brain radiation, cranial surgery no independent associations altered survival. CONCLUSIONS. The this study suggested different metastases. Further research into area may clarify causes discrepancy improve prognostication. Cancer 2007. © 2006 American Society.

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