Clinical effects of recent cocaine use on patients with acute schizophrenia.

摘要: Objective: Dopamine function has been hypothesized to be involved in both producing schizophrenic symptoms and mediating cocaine’s reinforcing properties. As a result, cocaine abuse patients may seen as natural experiment that alter the phenomenology neurobiology of schizophrenia. This report concerns clinical effects cessation at two times: when presented psychiatric emergency service again after 4 weeks ofhospitalization. Method: The subjects were 15 cocaine-abusing 22 cocaine-abstaining patients. Diagnostic assessments performed with Structured Clinical Interview for DSM-III-R-Patient Version, which uses DSM-III-R criteria. All assessed times BriefPsychiatric Rating Scale, Scale Assessment ofPositive Symptoms, Negative Symptoms. Results: Cocaine-abusing showed fewer negative signs more anxiety/depression hospital-admission assessment than their nonabusing counterparts. At retest, no group differences detected patients’ or mood symptoms. Severity positive was equal testing sessions. Conclusions: significant difference admission attributed neurobiological impact cocaine. role ofpsychostimulants is discussed. (Am J Psychiatry 1995; 152:1464-1469)