Effects of anipamil on electrocardiogram, plasma creatine kinase, and reperfusion arrhythmias after coronary occlusion in closed-chest rats.

摘要: The effect of anipamil pretreatment on ischemic electrocardiogram changes and loss creatine kinase (CK) after 3 h left anterior descending coronary artery (LAD) occlusion (group I) and, in a second set experiments, reperfusion arrhythmias 5 min II) closed-chest rats was investigated. An LAD occluder implanted animals under anaesthesia 8 days before occlusion. Rats group I were orally treated for with 6.0 mg/kg once daily; performed 4 the last treatment. Group II received single injection 0.5 or 1.0 intravenously 30 Oral significantly reduced CK compared untreated controls. Three hours occlusion, plasma 99 +/- 37 U/L 257 47 During first 10 delayed increases R wave ST segment. In experiments all control showed polymorphous ventricular tachycardia (VT) immediately restoration flow; 77% degenerated to fibrillation (VF). After i.v. VT observed 61% rats, VF only 14%; totally prevented animals. We conclude that reduces functional biochemical damage acute myocardial ischemia prevents reperfusion-induced rats.