Protective effects of calcium antagonists against ischaemia and reperfusion damage.

摘要: The most positive results in this area have been those of the second Danish Study Group on Verapamil Myocardial Infarction (1990) which assessed benefit treatment with verapamil from week after myocardial infarction. produced a significant reduction both mortality and reinfarction rates. Consequently, it may be concluded that calcium antagonists, such as diltiazem, should not used acute phase infarction, but rather prophylaxis to prevent by protecting against ischaemia. lack reported cardioprotective efficacy contrasts experimental predictions, can explained inappropriate timing administration use dihydropyridine, detrimental These is little or no evidence show antagonists are patients infarction unstable angina. Thus, randomised trials studying reveal overall effect short long term. prototype differ their effects rate these patients. With there small tendency for reinfarction, nifedipine clear worsening, diltiazem almost reaching statistical significance. general protective presumably result drugs being administered too late onset