The Future of Drug Discovery: The Importance of Modified Nucleosides, Nucleotides, and Oligonucleotides
作者： Anant R. Kapdi , Yogesh S. Sanghvi
DOI: 10.1016/B978-0-12-811292-2.00001-5
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摘要: Abstract This chapter summarizes various Pd-catalyzed cross-coupling reactions enabling the synthesis of chemically modified nucleic acid analogs with potential applications in therapeutic and diagnostic field, including design application novel fluorescent nucleoside analogs. A brief discussion all chapters this book describing prominent such as Stille, Suzuki-Miyaura, Sonogashira, Heck, Buchwald-Hartwig, C-H activation is offered, where Pd-mediated chemistry has been employed during assembly nucleosides, nucleotides, oligonucleotides.
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