Clinical review: Goal-directed therapy in high risk surgical patients

作者: Nicholas Lees , Mark Hamilton , Andrew Rhodes

DOI: 10.1186/CC8039

关键词:

摘要: A small group of patients account for the majority peri-operative morbidity and mortality. These 'high-risk' have a poor outcome due to their inability meet oxygen transport demands imposed on them by nature surgical response during period. It has been shown that targeting specific haemodynamic goals at any point period, outcomes these can be improved. This goal directed therapy includes use fluid loading inotropes, in order optimize preload, contractility afterload heart whilst maintaining an adequate coronary perfusion pressure. Despite benefits seen, it remains challenge implement this management difficulties identifying patients, scepticism lack critical care resources.

参考文章(71)
Paul C Hébert, George Wells, Morris A Blajchman, John Marshall, Claudio Martin, Giuseppe Pagliarello, Martin Tweeddale, Irwin Schweitzer, Elizabeth Yetisir, Transfusion Requirements in Critical Care Investigators for the Canadian Critical Care Trials Group, A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care The New England Journal of Medicine. ,vol. 340, pp. 409- 417 ,(1999) , 10.1056/NEJM199902113400601
Rupert M Pearse, David A Harrison, Philip James, David Watson, Charles Hinds, Andrew Rhodes, R Michael Grounds, E David Bennett, Identification and characterisation of the high-risk surgical population in the United Kingdom Critical Care. ,vol. 10, pp. 1- 6 ,(2006) , 10.1186/CC4928
Daniela S Patini, Adriana E Yamamoto, Neymar E de Oliveira, Patricia Serrano, Helder S Sanches, Marco A Spegiorin, Marcio M Queiroz, Antonio C Christiano, Elisangela F Savieiro, Paula A Alvarez, Silvia P Teixeira, Geni S Cunrath, Suzana M Lobo, Francisco R Lobo, Carlos A Polachini, Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141] Critical Care. ,vol. 10, pp. 1- 11 ,(2006) , 10.1186/CC4913
Owen Boyd, Neil Jackson, How is risk defined in high-risk surgical patient management? Critical Care. ,vol. 9, pp. 390- 396 ,(2005) , 10.1186/CC3057
Martijn Poeze, Jan Willem M Greve, Graham Ramsay, Meta-analysis of hemodynamic optimization: relationship to methodological quality. Critical Care. ,vol. 9, pp. 1- 9 ,(2005) , 10.1186/CC3902
Prytherch, Whiteley, Higgins, Weaver, Prout, Powell, POSSUM and Portsmouth POSSUM for predicting mortality British Journal of Surgery. ,vol. 85, pp. 1217- 1220 ,(2003) , 10.1046/J.1365-2168.1998.00840.X
Curran, Grounds, Ward versus intensive care management of high‐risk surgical patients British Journal of Surgery. ,vol. 85, pp. 956- 961 ,(2003) , 10.1046/J.1365-2168.1998.00731.X
Paul Older, Adrian Hall, Clinical review: How to identify high-risk surgical patients Critical Care. ,vol. 8, pp. 369- 372 ,(2004) , 10.1186/CC2848
Sarah Chieveley-Williams, Colin Hamilton-Davies, The Role of the Gut in Major Surgical Postoperative Morbidity International Anesthesiology Clinics. ,vol. 37, pp. 81- 110 ,(1999) , 10.1097/00004311-199903720-00006