Synergistic effects of stress and omega-3 fatty acid deprivation on emotional response and brain lipid composition in adult rats.
作者： G. Mathieu , S. Denis , M. Lavialle , S. Vancassel
DOI: 10.1016/J.PLEFA.2008.05.003
关键词:
摘要: The aim was to determine the consequences of multi-generational n-3 polyunsaturated fatty acids (PUFA) deficiency on emotional response in rats subjected maternal separation (MS) as chronic early life stress. Pups fed a control or an PUFA deficient diet were daily separated for 2 weeks before weaning. In adult rats, reward assessed by sucrose consumption and reactivity novelty using openfield test. Both MS increased impulsivity. Moreover, nutritional stress acted synergy elevate intake 80%, compared conditions. deprivation induced depletion docosahexanoeic acid brain membranes 70% compensated increase 22:5 n-6 arachidonic (AA) levels. diet-induced AA was, however, significantly higher rats. This suggests that deficit could be environmental risk increasing vulnerability depressive-like
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sci-hub.se 参考文章(54)
Sylvie Delion, Sylvie Chalon, Josiane Hérault, Denis Guilloteau, Jean-Claude Besnard, Georges Durand, Chronic dietary α-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats Journal of Nutrition. ,vol. 124, pp. 2466- 2476 ,(1994) , 10.1093/JN/124.12.2466
Akhlaq A. Farooqui, Lloyd A. Horrocks, Tahira Farooqui, Modulation of inflammation in brain: a matter of fat. Journal of Neurochemistry. ,vol. 101, pp. 577- 599 ,(2006) , 10.1111/J.1471-4159.2006.04371.X
Luc Zimmer, Sylvie Vancassel, Sylvain Cantagrel, Patrick Breton, Séraphin Delamanche, Denis Guilloteau, Georges Durand, Sylvie Chalon, The dopamine mesocorticolimbic pathway is affected by deficiency in n−3 polyunsaturated fatty acids The American Journal of Clinical Nutrition. ,vol. 75, pp. 662- 667 ,(2002) , 10.1093/AJCN/75.4.662
Keith Matthews, Naida Forbes, Ian C. Reid, Sucrose consumption as an hedonic measure following chronic unpredictable mild stress. Physiology & Behavior. ,vol. 57, pp. 241- 248 ,(1995) , 10.1016/0031-9384(94)00286-E
Makiko Umezawa, Akira Ohta, Hiromasa Tojo, Hideo Yagi, Masanori Hosokawa, Toshio Takeda, Dietary α-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM) Brain Research. ,vol. 669, pp. 225- 233 ,(1995) , 10.1016/0006-8993(94)01250-L
Andras Hajnal, Gerard P. Smith, Ralph Norgren, Oral sucrose stimulation increases accumbens dopamine in the rat American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 286, ,(2004) , 10.1152/AJPREGU.00282.2003
Marlene P. Freeman, Joseph R. Hibbeln, Katherine L. Wisner, John M. Davis, David Mischoulon, Malcolm Peet, Paul E. Keck, Lauren B. Marangell, Alexandra J. Richardson, James Lake, Andrew L. Stoll, Omega-3 fatty acids: Evidence basis for treatment and future research in psychiatry The Journal of Clinical Psychiatry. ,vol. 67, pp. 1954- 1967 ,(2006) , 10.4088/JCP.V67N1217
Richard P. Bazinet, Jagadeesh S. Rao, Lisa Chang, Stanley I. Rapoport, Ho-Joo Lee, Chronic Carbamazepine Decreases the Incorporation Rate and Turnover of Arachidonic Acid but Not Docosahexaenoic Acid in Brain Phospholipids of the Unanesthetized Rat: Relevance to Bipolar Disorder Biological Psychiatry. ,vol. 59, pp. 401- 407 ,(2006) , 10.1016/J.BIOPSYCH.2005.07.024
H Francès, P Draı̈, M Smirnova, I Carrié, M Debray, J.M Bourre, Nutritional (n-3) polyunsaturated fatty acids influence the behavioral responses to positive events in mice Neuroscience Letters. ,vol. 285, pp. 223- 227 ,(2000) , 10.1016/S0304-3940(00)01065-X
Paul M. Plotsky, Michael J. Meaney, Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats Molecular Brain Research. ,vol. 18, pp. 195- 200 ,(1993) , 10.1016/0169-328X(93)90189-V