How intravesicular composition affects exocytosis.
作者： R. Mark Wightman , Natalia Domínguez , Ricardo Borges
DOI: 10.1007/S00424-017-2035-6
关键词:
摘要: Large dense core vesicles and chromaffin granules accumulate solutes at large concentrations (for instance, catecholamines, 0.5–1 M; ATP, 120–300 mM; or Ca 2+, 40 mM (12)). Solutes seem to aggregate to a condensed protein matrix, which is mainly composed of chromogranins, to elude osmotic lysis. This association is also responsible for the delayed release of catecholamines during exocytosis. Here, we compile experimental evidence, obtained since the inception of single-cell amperometry, demonstrating how the alteration of …
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