Alphavirus Vectors for Therapy of Neurological Disorders

摘要: Alphavirus vectors engineered for gene delivery and expression of heterologous proteins have been considered as valuable tools research on neurological disorders. They possess a highly efficient susceptibility neuronal cells can provide extreme levels expression. However, they generally generate short-term transient expression, which might limit their therapeutic use in many disorders often requiring long-term even life-long presence agents. Recent development silencing applying both RNA interference microRNA approaches will certainly expand the application range. Moreover, alphaviruses interesting models diseases such demyelinating spinal motor diseases.