Effects of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats: A dose-response and curative effects study.
作者： Weiwei Feng , Guanghua Mao , Qian Li , Wei Wang , Yao Chen
DOI: 10.1111/JDI.12350
关键词:
摘要: Aims/Introduction The present study was designed to evaluate the effect of chromium malate on glycometabolism, glycometabolism-related enzyme levels and lipid metabolism in type 2 diabetic rats, dose–response curative effects. Materials Methods The model diabetes rats developed, daily treatment with given for 4 weeks. A rat enzyme-linked immunosorbent assay kit used changes. Results The results showed that antihyperglycemic activity increased administration a dose–dependent manner. The serum insulin level, resistance index C-peptide level groups at dose 17.5, 20.0 20.8 μg chromium/kg bodyweight were significantly lower than model, trichloride picolinate groups. hepatic glycogen, glucose-6-phosphate dehydrogenase glucokinase higher Chromium changed total cholesterol, low-density lipoprotein high-density triglycerides compared groups. Conclusions The exhibits greater benefits treating diabetes, is superior picolinate.
sci-hub.se 参考文章(39)
C T Chang, Y M Yu, C E Tsai, W C Chang, C L Hsieh, Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes. Diabetes & Metabolism. ,vol. 28, pp. 107- 114 ,(2002)
R A Anderson, Chromium in the prevention and control of diabetes Diabetes & Metabolism. ,vol. 26, pp. 22- 27 ,(2000)
Hirohide Yokokawa, Ikiko Kinoshita, Takeo Hashiguchi, Masako Kako, Kahoru Sasaki, Akira Tamura, Yuri Kintaka, Yoko Suzuki, Noriko Ishizuka, Katsumi Arai, Yoshiko Kasahara, Mikiko Kishi, Yoko Kobayashi, Tosei Takahashi, Hiroyuki Shimizu, Shuji Inoue, Enhanced exercise-induced muscle damage and muscle protein degradation in streptozotocin-induced type 2 diabetic rats. Journal of Diabetes Investigation. ,vol. 2, pp. 423- 428 ,(2011) , 10.1111/J.2040-1124.2011.00130.X
Ewelina Król, Zbigniew Krejpcio, Chromium(III) propionate complex supplementation improves carbohydrate metabolism in insulin-resistance rat model. Food and Chemical Toxicology. ,vol. 48, pp. 2791- 2796 ,(2010) , 10.1016/J.FCT.2010.07.008
B. Gammelgaard, K. Jensen, B. Steffansen, In vitro Metabolism and Permeation Studies in Rat Jejunum: Organic Chromium Compared to Inorganic Chromium Journal of Trace Elements in Medicine and Biology. ,vol. 13, pp. 82- 88 ,(1999) , 10.1016/S0946-672X(99)80028-5
Chang Lin, Po-Wen Chen, Wen-Ying Chen, Chi-Ching Sun, Frank Chiahung Mao, Glucagon and insulin have opposite effects on tissue chromium distribution in an obese mouse model Journal of Diabetes Investigation. ,vol. 4, pp. 528- 532 ,(2013) , 10.1111/JDI.12097
Elena M. Díaz-Medina, Domingo Martín-Herrera, Elena M. Rodríguez-Rodríguez, Carlos Díaz-Romero, Chromium(III) in cactus pad and its possible role in the antihyperglycemic activity Journal of Functional Foods. ,vol. 4, pp. 311- 314 ,(2012) , 10.1016/J.JFF.2011.12.009
Ewelina Król, Zbigniew Krejpcio, Evaluation of anti-diabetic potential of chromium(III) propionate complex in high-fat diet fed and STZ injected rats. Food and Chemical Toxicology. ,vol. 49, pp. 3217- 3223 ,(2011) , 10.1016/J.FCT.2011.09.006
Fang Li, Xiangyang Wu, Yanmin Zou, Ting Zhao, Min Zhang, Weiwei Feng, Liuqing Yang, Comparing anti-hyperglycemic activity and acute oral toxicity of three different trivalent chromium complexes in mice. Food and Chemical Toxicology. ,vol. 50, pp. 1623- 1631 ,(2012) , 10.1016/J.FCT.2012.02.012
Shilpi Sharma, Rajendra Prasad Agrawal, Maya Choudhary, Shreyans Jain, Shekhar Goyal, Vivek Agarwal, Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes Journal of Trace Elements in Medicine and Biology. ,vol. 25, pp. 149- 153 ,(2011) , 10.1016/J.JTEMB.2011.03.003