Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.
作者： K.-G. Weng , Y.-L. Yuan
DOI: 10.1590/1414-431X20176455
关键词:
摘要: Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized their structures determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, single crystal X-ray crystallography. Additionally, the new compounds evaluated to identify molecular characteristics that contribute cytotoxicity, which was tested against SK-LU-1, SPC-A-1 95D human lung cancer cell lines, using MTT assay. The results this study showed Ic, Id, IIc, IId exhibited an efficient percentage inhibition proliferation.
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Jing Li, Xiao-yan Xue, Xia Li, Zheng Hou, Xiao-hui Yang, Di Qu, Ying Zhou, Zi-dan Zhang, Xiao-xing Luo, Jiang-tao Li, Ming-kai Li, Synthesis of biscoumarin and dihydropyran derivatives as two novel classes of potential anti-bacterial derivatives Archives of Pharmacal Research. ,vol. 39, pp. 1349- 1355 ,(2016) , 10.1007/S12272-015-0614-7
Y.-C. Wang, U. Bachrach, The specific anti-cancer activity of green tea (−)-epigallocatechin-3-gallate (EGCG) Amino Acids. ,vol. 22, pp. 131- 143 ,(2002) , 10.1007/S007260200002
Jing Li, Yun-Peng Sui, Jia-Jia Xin, Xin-Liang Du, Jiang-Tao Li, Hai-Ru Huo, Hai Ma, Wei-Hao Wang, Hai-Yu Zhou, Hong-Dan Zhan, Zhu-Ju Wang, Chun Li, Feng Sui, Xia Li, Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities Bioorganic & Medicinal Chemistry Letters. ,vol. 25, pp. 5520- 5523 ,(2015) , 10.1016/J.BMCL.2015.10.063
Wei Wang, Yuqing Zhao, Elizabeth R. Rayburn, Donald L. Hill, Hui Wang, Ruiwen Zhang, In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemotherapy and Pharmacology. ,vol. 59, pp. 589- 601 ,(2007) , 10.1007/S00280-006-0300-Z
Bin Bao, Shadan Ali, Dejuan Kong, Sanila H. Sarkar, Zhiwei Wang, Sanjeev Banerjee, Amro Aboukameel, Subhash Padhye, Philip A. Philip, Fazlul H. Sarkar, Anti-Tumor Activity of a Novel Compound-CDF Is Mediated by Regulating miR-21, miR-200, and PTEN in Pancreatic Cancer PLoS ONE. ,vol. 6, pp. e17850- ,(2011) , 10.1371/JOURNAL.PONE.0017850
Yang Yi, Sen-Tai Liao, Ming-Wei Zhang, Rui-Fen Zhang, Yuan-Yuan Deng, Bao Yang, Zhen-Cheng Wei, Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp Molecules. ,vol. 16, pp. 10324- 10336 ,(2011) , 10.3390/MOLECULES161210324
Christos A. Kontogiorgis, Dimitra J. Hadjipavlou-Litina, Synthesis and antiinflammatory activity of coumarin derivatives Journal of Medicinal Chemistry. ,vol. 48, pp. 6400- 6408 ,(2005) , 10.1021/JM0580149
Hailong Yu, Qingrong Huang, Enhanced in vitro anti-cancer activity of curcumin encapsulated in hydrophobically modified starch Food Chemistry. ,vol. 119, pp. 669- 674 ,(2010) , 10.1016/J.FOODCHEM.2009.07.018
Belén Zarranz, Andrés Jaso, Ignacio Aldana, Antonio Monge, Synthesis and anticancer activity evaluation of new 2-alkylcarbonyl and 2-benzoyl-3-trifluoromethyl-quinoxaline 1,4-di-N-oxide derivatives. Bioorganic & Medicinal Chemistry. ,vol. 12, pp. 3711- 3721 ,(2004) , 10.1016/J.BMC.2004.04.013
Jing Li, Chang-Wei Lv, Xiao-Jun Li, Di Qu, Zheng Hou, Min Jia, Xiao-Xing Luo, Xia Li, Ming-Kai Li, Synthesis of Biscoumarin and Dihydropyran Derivatives and Evaluation of Their Antibacterial Activity Molecules. ,vol. 20, pp. 17469- 17482 ,(2015) , 10.3390/MOLECULES200917469