A unique pancreatic ductal adenocarcinoma with carcinosarcomatous histology, immunohistochemical distribution of hCG-beta, and the elevation of serum alpha-feto-protein.

摘要: Pancreatic undifferentiated carcinomas with a neoplastic mesenchymal component (carcinosarcoma) have not been well described to date. The author experienced an autopsy case of unique pancreatic ductal adenocarcinoma carcinosarcomatous histology. patient was 90 year old Japanese male who died cahexia generalized tumor extension. Post-mortem examinations revealed some distinctive or representative components discerned in the tissue. One differentiated adenocarcinoma. second and major finding short spindle shaped small round sarcomatous cells, which lacked epithelial nature but showed positivity for CD10+, CD56+, Ki67++, p53++, were focally positive Desmin vimentin. These two mixed constituted histology carcinosarcoma. In another area, anaplastic, large, pleomorphic cells focal immunohistochemical distribution alpha-feto-protein human chorionic gonadotropin. An ultrastructural study apical mucin secreting granules developed differentiation, whereas primitive fibroblastic characters without specific differentiation. Conclusively these findings suggested that this gradually enlarged, accumulated genetic alternations, then transformed into large rapidly growing