B7 Costimulatory Requirements of T Cells at an Inflammatory Site

摘要: The requirement for T cell costimulation at sites of infection and inflammation is unresolved. Herpes stromal keratitis (HSK) a CD4+ cell-regulated inflammatory response to herpes simplex virus type 1 the cornea. Our findings suggest that susceptibility HSK determined by microenvironment infected cornea normally devoid Langerhans cells (LC), but these APC are present in surrounding conjunctiva, migrate into following infection. costimulatory molecule B7-2 was constitutively expressed on LC B7-1 not detectable until 3 days postinfection. were only through 7 some, all, migrating LC, suggesting migration expression can be independently regulated. early independent cells, required massive accumulation B7-1+ onset inflammation. Local inhibition function within prevented HSK. Locally blocking did reduce incidence, markedly severity. This first direct demonstration naturally B7 an site.