A crucial role for B and T lymphocyte attenuator in preventing the development of CD4+ T cell-mediated herpetic stromal keratitis

作者: Shengnan Zhang , Yan Li , Likun Xia , Jiazi Zhou

DOI:

关键词: InflammationKeratitisT lymphocyteReceptorBiologyBTLADownregulation and upregulationImmunologyCluster of differentiationImmunopathology

摘要: Purpose To investigate the effect of B and T lymphocyte attenuator (BTLA; CD272) on cluster differentiation (CD)4+ cell-mediated corneal immunopathology during murine herpetic stromal keratitis (HSK).

参考文章(40)
B R Ksander, R L Hendricks, Cell-mediated immune tolerance to HSV-1 antigens associated with reduced susceptibility to HSV-1 corneal lesions. Investigative Ophthalmology & Visual Science. ,vol. 28, pp. 1986- 1993 ,(1987)
R N Lausch, C Monteiro, J E Oakes, W R Kleinschradt, S G Kayes, Resolution of HSV corneal infection in the absence of delayed-type hypersensitivity. Investigative Ophthalmology & Visual Science. ,vol. 26, pp. 1509- 1515 ,(1985)
B T Rouse, M G Niemialtowski, Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis. Journal of Immunology. ,vol. 149, pp. 3035- 3039 ,(1992)
Christine Deppong, Jessica M. Degnan, Theresa L. Murphy, Kenneth M. Murphy, Jonathan M. Green, B and T Lymphocyte Attenuator Regulates T Cell Survival in the Lung Journal of Immunology. ,vol. 181, pp. 2973- 2979 ,(2008) , 10.4049/JIMMUNOL.181.5.2973
Robert L. Hendricks, Haixiao Chen, B7 Costimulatory Requirements of T Cells at an Inflammatory Site Journal of Immunology. ,vol. 160, pp. 5045- 5052 ,(1998)
Michelle A. Hurchla, John R. Sedy, Maya Gavrielli, Charles G. Drake, Theresa L. Murphy, Kenneth M. Murphy, B and T Lymphocyte Attenuator Exhibits Structural and Expression Polymorphisms and Is Highly Induced in Anergic CD4+ T Cells Journal of Immunology. ,vol. 174, pp. 3377- 3385 ,(2005) , 10.4049/JIMMUNOL.174.6.3377
R L Hendricks, A Finnegan, T M Tumpey, IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice. Journal of Immunology. ,vol. 149, pp. 3023- 3028 ,(1992)
Su K Seo, Hye Y Park, Jae H Choi, Won Y Kim, Young H Kim, Hyo W Jung, Byungsuk Kwon, Hyeon W Lee, Byoung S Kwon, None, Blocking 4-1BB/4-1BB ligand interactions prevents herpetic stromal keratitis. Journal of Immunology. ,vol. 171, pp. 576- 583 ,(2003) , 10.4049/JIMMUNOL.171.2.576
B T Rouse, M G Niemialtowski, Phenotypic and functional studies on ocular T cells during herpetic infections of the eye. Journal of Immunology. ,vol. 148, pp. 1864- 1870 ,(1992)
Jason K Whitmire, Richard A Flavell, Iqbal S Grewal, Christian P Larsen, Thomas C Pearson, Rafi Ahmed, None, CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses. Journal of Immunology. ,vol. 163, pp. 3194- 3201 ,(1999)