Topical Use of Rapamycin in Herpetic Stromal Keratitis

作者: Gustavo Zapata , Lourdes Racca , Julia Tau , Alejandro Berra

DOI: 10.3109/09273948.2012.709575

关键词:

摘要: Purpose: To evaluate and compare the efficacy of rapamycin used topically in a mouse model herpetic stromal keratitis.Methods: The corneas were infected with herpes simplex virus type-1 strain KOS. Animals divided into: control (CG), (RAPA), cyclosporine (CsA), dexamethasone (DEXA). evolution disease was assessed clinically histologically.Results: On day 10 postinfection (pi), RAPA group showed only significantly lower angiogenic development than CG. 14 pi, treated groups had scores for angiogenesis necrosis Also, on DEXA histopathological compared to CG.Conclusions: topical application 0.05% greater 0.5% similar 0.1% minimize immuno-inflammatory process. early inhibition formation new vessels.

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