Involvement of Monocarboxylate Transporter 4 Expression in Statin-Induced Cytotoxicity

摘要: Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are the most widely used cholesterol-lowering agents for prevention of obstructive cardiovascular events. However, statins can cause a variety skeletal muscle problems, and exercise leads to an increase in statin-induced injury. Exercise induces protein content monocarboxylate transporter 4 (MCT4), which is expressed strongly thought play major role transport metabolically important monocarboxylates such as l-lactate. We previously reported that α-cyano-4-hydroxycinnamate, MCT4 inhibitor, increased inhibition growth RD cells, prototypic embryonal rhabdomyosarcoma cell line (an line), model in vitro muscle, induced by statin. it unclear whether cytotoxicity associated with expression. We, therefore, examined relationship between expression cells. Atorvastatin reduced number viable cells upregulated MCT4, but not MCT1, mRNA level concentration-dependent manner. knockdown suppressed atorvastatin-, simvastatin-, fluvastatin-induced reduction viability apoptosis compared negative control-treated In this study, we demonstrated cytotoxicity.