Localization of EFA6A, a guanine nucleotide exchange factor for ARF6, in spermatogenic cells of testes of adult mice.

作者: Ryoji Suzuki , Sachiko Saino-Saito , Hiroyuki Sakagami , Kiyotaka Toshimori , Hiroshi Abe

DOI: 10.1007/S10735-008-9207-9

关键词:

摘要: ADP ribosylation factors (ARFs) of small GTPase are molecular switches regulating various membrane dynamics. Among them, ARF6 has recently been highlighted because its function to facilitate the interaction between cytoskeleton and plasma membrane. Each ARFs preferable or even specific guanine nucleotide exchange (GEFs) as activators. According our previous RT-PCR analysis, EFA6A, a factor for ARF6, was restrictedly expressed in brain, retina testis. Different from studies on neurons, first shown be localized intensely nuclei spermatocytes adult mouse testes present immunohistochemical study. This suggests possible involvement EFA6A-ARF6 signaling karyokinesis cytokinesis.

参考文章(19)
M Tsuchiya, S R Price, S C Tsai, J Moss, M Vaughan, Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. Journal of Biological Chemistry. ,vol. 266, pp. 2772- 2777 ,(1991) , 10.1016/S0021-9258(18)49913-9
Eric Schonteich, Manohar Pilli, Glenn C. Simon, Hugo T. Matern, Jagath R. Junutula, Danielle Sentz, Randall K. Holmes, Rytis Prekeris, Molecular characterization of Rab11-FIP3 binding to ARF GTPases European Journal of Cell Biology. ,vol. 86, pp. 417- 431 ,(2007) , 10.1016/J.EJCB.2007.05.004
Hiroyuki Sakagami, Hiroharu Suzuki, Akifumi Kamata, Yuji Owada, Kohji Fukunaga, Hideaki Mayanagi, Hisatake Kondo, Distinct spatiotemporal expression of EFA6D, a guanine nucleotide exchange factor for ARF6, among the EFA6 family in mouse brain. Brain Research. ,vol. 1093, pp. 1- 11 ,(2006) , 10.1016/J.BRAINRES.2006.02.058
Jillian L. Dunphy, Keqiang Ye, James E. Casanova, Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2 Traffic. ,vol. 8, pp. 661- 672 ,(2007) , 10.1111/J.1600-0854.2007.00561.X
Julie G. Donaldson, Multiple Roles for Arf6: Sorting, Structuring, and Signaling at the Plasma Membrane Journal of Biological Chemistry. ,vol. 278, pp. 41573- 41576 ,(2003) , 10.1074/JBC.R300026200
Chun Zhi Yang, Harry Heimberg, Crislyn D’Souza-Schorey, Mike M. Mueckler, Philip D. Stahl, Subcellular Distribution and Differential Expression of Endogenous ADP-ribosylation Factor 6 in Mammalian Cells Journal of Biological Chemistry. ,vol. 273, pp. 4006- 4011 ,(1998) , 10.1074/JBC.273.7.4006
Catherine L. Jackson, James E. Casanova, Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors Trends in Cell Biology. ,vol. 10, pp. 60- 67 ,(2000) , 10.1016/S0962-8924(99)01699-2
Jill Kuglin Schweitzer, Crislyn D'Souza-Schorey, A requirement for ARF6 during the completion of cytokinesis. Experimental Cell Research. ,vol. 311, pp. 74- 83 ,(2005) , 10.1016/J.YEXCR.2005.07.033
Mira Hazzouri, Christophe Pivot-Pajot, Anne-Karen Faure, Yves Usson, Roberte Pelletier, Bernard Sèle, Saadi Khochbin, Sophie Rousseaux, Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylases. European Journal of Cell Biology. ,vol. 79, pp. 950- 960 ,(2000) , 10.1078/0171-9335-00123
NICOLAS VITALE, SYLVETTE CHASSEROT-GOLAZ, MARIE-FRANCE BADER, Regulated Secretion in Chromaffin Cells Annals of the New York Academy of Sciences. ,vol. 971, pp. 193- 200 ,(2002) , 10.1111/J.1749-6632.2002.TB04463.X