Mental nerve injury induces novelty seeking behaviour leading to increasing ethanol intake in Wistar rats.

摘要: Abstract Objective Dental treatment and orofacial surgeries may induce chronic neuropathic pain (CNOP). This kind of affects adaptability to environmental changes in both model animals humans. Part the adaptation process depends on ability distinguish between familiar novel stimuli. CNOP induces novelty seeking behaviour as a deficit adaptation. Alternatively, is sign for susceptibility development substance abuse. Evidence shows that leads alcoholism animal models. The behavioural relationship CNOP, abuse unknown. In this article, we investigate if produces an increase increasing ethanol intake. Design Firstly, used mental nerve injury evaluate thermal mechanical allodynia. We recognition task determine drink darkness protocol assess Results Our results show constriction increases (p = 0.01) correlates with binge consumption (r2 = 0.68, p = 0.0008). Conclusions present study demonstrates, first time, trigeminal injury, which enough provide lead can serve predictor risk developing involves high producing addiction. level evaluation patients before critical.