The Effect of Hypophysectomy on Somatostatin-Like Immunoreactivity in Discrete Hypothalamic and Extrahypothalamic Nuclei*

摘要: Several hypothalamic and extrahypothalamic sites that have high concentrations of somatostatin-positive nerve terminals and/or cell bodies are important in the regulation GH secretion. is capable inhibiting its own secretion under certain prescribed conditions, a short loop feedback regulatory mechanism may involve somatostatinergic pathways. The purpose this investigation was to determine effect removal by hypophysectomy on content somatostatin- like immunoreactivity (SLI) discrete nuclei. Individual nuclei were removed from frozen brain sections hypophysectomized sham-operated male rats. tissue somatostatin determined specific RIA. SLI median eminence animals significantly reduced 38%, compared shamoperated controls (278 ± 53.2 vs. 447.0 57.4 pg/μg protein, respectively). Significant reductions medial preoptic (50%), arcuate (33%), ...