Hypothalamic somatostatin-14 and -28 biosynthesis: effects of anesthetics and hypophysectomy.

作者: Christina M. Van Itallie , John D. Fernstrom

DOI: 10.1016/0006-8993(82)90185-8

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摘要: Abstract Somatostatin-14 and -28 biosynthesis in rat hypothalami was assessed following intracerebroventricular injection of [35S]cysteine, subsequent reversed-phase HPLC separation the labeled peptides. Identities somatostatin-14 were verified using 3 buffer systems. The anesthetic employed during label administration itself influenced [35S]cysteine incorporation into both somatostatins. Hypophysectomy diminished peptides, suggesting that somatostatin has an inhibitory role control growth hormone secretion.

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